In the UK there are approximately 850,000 new fractures seen each year, while it has been suggested that approximately 5-10% of such fractures are fractures in which the fractured bone fails to heal, medically referred to as nonunion fractures. The cost to the National Health Service of treating non-union fractures has been reported to range between £18,000 and £79,000 per person. The estimated addressable market for nonunion and enhanced healing of fractures for the EU is approximately 0.7 to 2 billion Euros per year, assuming an expense of approximately 2,000 to 2,500 Euro per treatment regimen. In the U.S there are approximately seven million new fractures/broken bones each year, with approximately 300,000 developing slowly (delayed union) or nonunion fractures. Estimates for the average non-union treatment cost vary from nearly $25,000 to $45,000. Nonunions are estimated to cost the health care system in the US $9.2 billion/ year. This excludes losses in productivity to the economy.
Retrospective studies have found that 8.3% to 52% of runners have had a history of stress fracture, whereas the incidence in a 12-month prospective study of track and field athletes was 21.1%. When expressed as a percentage of all injuries, stress fractures have been reported to represent between 0.5% and 20.0% of all injuries sustained by athletic populations. Prospective data in recruits undergoing basic training indicate a stress fracture incidence of 3.3% to 8.5% in the US military and 3.6% to 28.9% in the Israeli military.